UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*

                          Keryx Biopharmaceuticals Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, $0.001 Par Value Per Share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    492515101
                                    ---------
                                 (CUSIP Number)

                                December 28, 2004
                                -----------------
                      (Date of Event which Requires Filing
                               of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule
                                    is filed:

                                [ ] Rule 13d-1(b)
                                [X] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)



*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


                                  Page 1 of 13




-------------------                                           ------------------
CUSIP No. 492515101                    13G                    Page 2 of 13 Pages
-------------------                                           ------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Advisors, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [ ]

                                                                         (b) [X]

---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------- ----- ----------------------------------------------------
                         5  SOLE VOTING POWER

                            0
                      ----- ----------------------------------------------------
NUMBER OF                6  SHARED VOTING POWER
SHARES
BENEFICIALLY                1,790,106 (includes 94,118 Shares issuable upon
OWNED                       exercise of warrants) (see Item 4)
BY                    ----- ----------------------------------------------------
EACH                     7  SOLE DISPOSITIVE POWER
REPORTING
PERSON                                  0
WITH                  ----- ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            1,790,106 (includes 94,118 Shares issuable upon
                            exercise of warrants) (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,790,106 (includes 94,118 Shares issuable upon exercise of warrants)
           (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.7% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 2 of 13




-------------------                                           ------------------
CUSIP No. 492515101                    13G                    Page 3 of 13 Pages
-------------------                                           ------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Management, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [ ]

                                                                         (b) [X]

---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------- ----- ----------------------------------------------------
                         5  SOLE VOTING POWER

                            0
                      ----- ----------------------------------------------------
NUMBER OF                6  SHARED VOTING POWER
SHARES
BENEFICIALLY                1,790,106 (includes 94,118 Shares issuable upon
OWNED                       exercise of warrants) (see Item 4)
BY                    ----- ----------------------------------------------------
EACH                     7  SOLE DISPOSITIVE POWER
REPORTING
PERSON                                  0
WITH                  ----- ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            1,790,106 (includes 94,118 Shares issuable upon
                            exercise of warrants) (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,790,106 (includes 94,118 Shares issuable upon exercise of warrants)
           (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.7% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 3 of 13




-------------------                                           ------------------
CUSIP No. 492515101                    13G                    Page 4 of 13 Pages
-------------------                                           ------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Associates, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [ ]

                                                                         (b) [X]

---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
-------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
NUMBER OF                6  SHARED VOTING POWER
SHARES
BENEFICIALLY                920,000 (see Item 4)
OWNED                ------ ----------------------------------------------------
BY                       7  SOLE DISPOSITIVE POWER
EACH
REPORTING                   0
PERSON               ------ ----------------------------------------------------
WITH                     8  SHARED DISPOSITIVE POWER

                            920,000 (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           920,000 (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           3.0% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 4 of 13




-------------------                                           ------------------
CUSIP No. 492515101                    13G                    Page 5 of 13 Pages
-------------------                                           ------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Healthco Fund, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [ ]

                                                                         (b) [X]

---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
-------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
NUMBER OF                6  SHARED VOTING POWER
SHARES
BENEFICIALLY                814,706 (includes 94,118 Shares issuable upon
OWNED                       exercise of warrants) (see Item 4)
BY                   ------ ----------------------------------------------------
EACH                     7  SOLE DISPOSITIVE POWER
REPORTING
PERSON                                  0
WITH                 ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            814,706 (includes 94,118 Shares issuable upon
                            exercise of warrants) (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           814,706 (includes 94,118 Shares issuable upon exercise of warrants)
           (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           2.6% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 5 of 13




-------------------                                           ------------------
CUSIP No. 492515101                    13G                    Page 6 of 13 Pages
-------------------                                           ------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. MultiQuant Fund, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [ ]

                                                                         (b) [X]

---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
-------------------- ------ ----------------------------------------------------
                         5  SOLE VOTING POWER

                            0
NUMBER OF            ------ ----------------------------------------------------
SHARES                   6  SHARED VOTING POWER
BENEFICIALLY
OWNED                       55,400 (see Item 4)
BY                   ------ ----------------------------------------------------
EACH                     7  SOLE DISPOSITIVE POWER
REPORTING
PERSON                      0
WITH                 ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            55,400 (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           55,400 (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           Less than 0.1% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 6 of 13




-------------------                                           ------------------
CUSIP No. 492515101                    13G                    Page 7 of 13 Pages
-------------------                                           ------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Steven A. Cohen
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [ ]

                                                                         (b) [X]

---------- ---------------------------------------------------------------------
        3  SEC USE ONLY
---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
--------------------- ----- ----------------------------------------------------
                         5  SOLE VOTING POWER

                            0
                      ----- ----------------------------------------------------
NUMBER OF                6  SHARED VOTING POWER
SHARES
BENEFICIALLY                1,790,106 (includes 94,118 Shares issuable upon
OWNED                       exercise of warrants) (see Item 4)
BY                    ----- ----------------------------------------------------
EACH                     7  SOLE DISPOSITIVE POWER
REPORTING
PERSON                      0
WITH                  ----- ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            1,790,106 (includes 94,118 Shares issuable upon
                            exercise of warrants) (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,790,106 (includes 94,118 Shares issuable upon exercise of warrants)
           (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.7% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           IN
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 7 of 13




Item 1(a)           Name of Issuer:
                    ---------------

                    Keryx Biopharmaceuticals Inc.

Item 1(b)           Address of Issuer's Principal Executive Offices:
                    ------------------------------------------------

                    750 Lexington Avenue
                    New York, New York 10022

Items 2(a)          Name of Person Filing:

                    This statement is filed by: (i) S.A.C. Capital Advisors,
                    LLC, ("SAC Capital Advisors") with respect to Shares
                    beneficially owned by S.A.C. Capital Associates, LLC ("SAC
                    Capital Associates"), S.A.C. Healthco Fund, LLC ("SAC
                    Healthco") and S.A.C. MultiQuant Fund, LLC ("SAC
                    MultiQuant"); (ii) S.A.C. Capital Management, LLC, ("SAC
                    Capital Management") with respect to Shares beneficially
                    owned by SAC Capital Associates, SAC Healthco and SAC
                    MultiQuant; (iii) SAC Capital Associates with respect to
                    Shares beneficially owned by it; (iv) SAC Healthco with
                    respect to Shares beneficially owned by it; (v) SAC
                    MultiQuant with respect to Shares beneficially owned by it;
                    (vi) Steven A. Cohen with respect to Shares beneficially
                    owned by SAC Capital Advisors, SAC Capital Management, SAC
                    Capital Associates, SAC Healthco and SAC MultiQuant.

Item 2(b)           Address of Principal Business Office:
                    -------------------------------------

                    The address of the principal business office of (i) SAC
                    Capital Advisors and Mr. Cohen is 72 Cummings Point Road,
                    Stamford, Connecticut 06902, (ii) SAC Capital Management is
                    540 Madison Avenue, New York, New York 10022, and (iii) SAC
                    Capital Associates, SAC Healthco and SAC MultiQuant is P.O.
                    Box 58, Victoria House, The Valley, Anguilla, British West
                    Indies.

Item 2(c)           Citizenship:
                    ------------

                    SAC Capital Advisors and SAC Capital Management are Delaware
                    limited liability companies. SAC Capital Associates, SAC
                    Healthco and SAC MultiQuant are Anguillan limited liability
                    companies. Mr. Cohen is a United States citizen.


                                  Page 8 of 13




Item 2(d)           Title of Class of Securities:
                    -----------------------------

                    Common Stock, par value $0.001 per share

Item 2(e)           CUSIP Number:
                    -------------

                    492515101

Item 3              Not Applicable

Item 4              Ownership:
                    ----------

                    The percentages used herein are calculated based upon the
                    Shares issued and outstanding as of November 5, 2004 as
                    reported on the Company's quarterly report on Form 10-Q
                    filed with the Securities and Exchange Commission by the
                    Issuer for the quarterly period ended September 30, 2004.

                    As of the close of business on December 29, 2004:

                    1. S.A.C. Capital Advisors, LLC
                    (a) Amount beneficially owned: 1,790,106
                    (includes 94,118 Shares issuable upon
                    exercise of warrants) 
                    (b) Percent of class: 5.7%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 1,790,106
                    (includes 94,118 Shares issuable upon exercise of warrants)
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    1,790,106 (includes 94,118 Shares issuable upon exercise of
                    warrants)

                    2. S.A.C. Capital Management, LLC
                    (a) Amount beneficially owned: 1,790,106 (includes 94,118
                    Shares issuable upon exercise of warrants)
                    (b) Percent of class: 5.7%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 1,790,106
                    (includes 94,118 Shares issuable upon exercise of warrants)
                    (iii) Sole power to dispose or direct the
                    disposition: -0- 
                    (iv) Shared power to dispose or direct the disposition:
                    1,790,106 (includes 94,118 Shares issuable upon exercise of
                    warrants)


                                  Page 9 of 13




                    3. S.A.C. Capital Associates, LLC
                    (a) Amount beneficially owned: 920,000
                    (b) Percent of class: 3.0%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 920,000
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    920,000

                    4. S.A.C. Healthco Fund, LLC
                    (a) Amount beneficially owned: 814,706 (includes 94,118
                    Shares issuable upon exercise of warrants)
                    (b) Percent of class: 2.6%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 814,706
                    (includes 94,118 Shares issuable upon exercise of warrants)
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    814,706 (includes 94,118 Shares issuable upon exercise of
                    warrants)

                    5. S.A.C. MultiQuant Fund, LLC
                    (a) Amount beneficially owned: 55,400
                    (b) Percent of class: Less than 0.1%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 55,400
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    55,400

                    6. Steven A. Cohen
                    (a) Amount beneficially owned: 1,790,106 (includes 94,118
                    Shares issuable upon exercise of warrants)
                    (b) Percent of class: 5.7%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 1,790,106
                    (includes 94,118 Shares issuable upon exercise of warrants)
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    1,790,106 (includes 94,118 Shares issuable upon exercise of
                    warrants)

                    SAC Capital Advisors, SAC Capital Management, and Mr. Cohen
                    own directly no shares of Common Stock. Pursuant to
                    investment agreements, each of SAC Capital Advisors and SAC
                    Capital Management share all investment and voting power
                    with respect to the securities held by SAC Capital
                    Associates, SAC Healthco and SAC MultiQuant. Mr. Cohen
                    controls each of SAC Capital Advisors and SAC Capital
                    Management. By reason of the provisions of Rule 13d-3 of the
                    Securities Exchange Act of 1934,


                                 Page 10 of 13




                    as amended, each of SAC Capital Advisors, SAC Capital
                    Management and Mr. Cohen may be deemed to own beneficially
                    1,790,106 Shares (includes 94,118 Shares issuable upon
                    exercise of warrants) (constituting approximately 5.7% of
                    the Shares outstanding). Each of SAC Capital Advisors, SAC
                    Capital Management, and Mr. Cohen disclaim beneficial
                    ownership of any of the securities covered by this
                    statement.

Item 5              Ownership of Five Percent or Less of a Class:
                    ---------------------------------------------

                    If this statement is being filed to report the fact that as
                    of the date hereof the reporting person has ceased to be the
                    beneficial owner of more than five percent of the class of
                    securities, check the following. [ ]

Item 6              Ownership of More than Five Percent on Behalf of Another
                    --------------------------------------------------------
                    Person:
                    -------

                    Not Applicable

Item 7              Identification and Classification of the Subsidiary Which
                    ---------------------------------------------------------
                    Acquired the Security Being Reported on By the Parent
                    -----------------------------------------------------
                    Holding Company:
                    ----------------

                    Not Applicable

Item 8              Identification and Classification of Members
                    --------------------------------------------
                    of the Group:
                    -------------

                    Not Applicable

Item 9              Notice of Dissolution of Group:
                    -------------------------------

                    Not Applicable

Item 10             Certification:
                    --------------

     By signing below the signatory certifies that, to the best of his knowledge
and belief, the securities referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing the control of
the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or
effect.


                                 Page 11 of 13




                                    SIGNATURE
                                    ---------

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Dated: December 30, 2004


S.A.C. CAPITAL ADVISORS, LLC

By: /s/ Peter Nussbaum
    ------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


S.A.C. CAPITAL MANAGEMENT, LLC

By: /s/ Peter Nussbaum
    ------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


S.A.C. CAPITAL ASSOCIATES, LLC

By: /s/ Peter Nussbaum
    ------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


S.A.C. HEALTHCO FUND, LLC

By: /s/ Peter Nussbaum
    ------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


                                 Page 12 of 13




S.A.C. MULTIQUANT FUND, LLC

By: /s/ Peter Nussbaum
    ------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


STEVEN A. COHEN

By: /s/ Peter Nussbaum
    ------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


                                 Page 13 of 13