UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

            --------------------------------------------------------


                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       Date of report (Date of earliest event reported): October 30, 2003
                                                         ----------------

                               CYTOGEN CORPORATION
            --------------------------------------------------------
               (Exact Name of Registrant as Specified in Charter)

           Delaware                     000-14879                 22-2322400
----------------------------    ------------------------     -------------------
(State or Other Jurisdiction    (Commission File Number)      (I.R.S. Employer
      of Incorporation)                                      Identification No.)

650 College Road East, CN 5308, Suite 3100, Princeton, NJ               08540
---------------------------------------------------------           ------------
        (Address of Principal Executive Offices)                     (Zip Code)

       Registrant's telephone number, including area code: (609) 750-8200
                                                           --------------





ITEM 5.     OTHER EVENTS.

     On October 30, 2003,  Matritech,  Inc. and Cytogen Corporation  executed an
amendment and restatement of the Distribution  Agreement originally entered into
by the parties on October 18, 2002 (the "Restated  Agreement").  Under the terms
of the Restated Agreement,  which takes effect on November 8, 2003, Cytogen will
have a non-exclusive right to sell  NMP22(R)BladderChek(TM)  to urologists until
December  31, 2003 and an  exclusive  right to continue to sell  BladderChek  to
oncologists  for the term of the  Restated  Agreement.  The term of the Restated
Agreement expires on December 31, 2004 and is renewable annually thereafter upon
the mutual  consent of the  parties.  The parties also have agreed to remove the
requirement  that Cytogen  sell a minimum  quantity of  BladderChek  in order to
maintain its exclusivity.

ITEM 7.     FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

            (c) Exhibits.

            EXHIBIT NO.      DESCRIPTION
            -----------      -----------

               99.1          Press Release of Cytogen Corporation dated November
                             3, 2003.






                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly caused this current report on Form 8-K to be signed on
its behalf by the undersigned hereunto duly authorized.

                              CYTOGEN CORPORATION



                              By:   /s/ Michael D. Becker
                                    -----------------------------------------
                                    Michael D. Becker
                                    President and Chief Executive Officer

Dated:   November 3, 2003






                                  EXHIBIT INDEX


            EXHIBIT NO.      DESCRIPTION
            -----------      -----------

               99.1          Press release of Cytogen Corporation dated November
                             3, 2003.