UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G


                    Under the Securities Exchange Act of 1934

                               (Amendment No. 4 )*

                                 ILLUMINA, INC.

                                (Name of Issuer)

                                  COMMON STOCK

                         (Title of Class of Securities)

                                    452327109

                                 (CUSIP Number)


                                February 29, 2008

             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

            X    Rule 13d-1(b)
         ------

         ____  Rule 13d-1(c)

         ____  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).






CUSIP No. 452327109
----------------------------------------------------------------------------

         1. Names of Reporting Persons.
              I.R.S. Identification Nos. of above persons (entities only).
Federated Investors, Inc.

         2. Check the Appropriate Box if a Member of a Group (See Instructions)

              (a)...............................................................

              (b)...............................................................

         3.   SEC Use Only......................................................

         4.   Citizenship or Place of Organization:  Pennsylvania

Number of             5.   Sole Voting Power  2,350,440
Shares Bene-
ficially by           6.   Shared Voting Power
Owned by Each
Reporting             7.   Sole Dispositive Power  2,350,440
Person With:
                      8.   Shared Dispositive Power

         9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,350,440

         10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)

         11. Percent of Class Represented by Amount in Row (9) 4.22%

         12. Type of Reporting Person (See Instructions) HC

         1. Names of Reporting Persons.
              I.R.S. Identification Nos. of above persons (entities only).
Voting Shares Irrevocable Trust

         2. Check the Appropriate Box if a Member of a Group (See Instructions)

              (a)...............................................................

              (b)...............................................................

         3.   SEC Use Only......................................................

         4.   Citizenship or Place of Organization:  Pennsylvania

Number of             5.   Sole Voting Power  2,350,440
Shares Bene-
ficially by           6.   Shared Voting Power
Owned by Each
Reporting             7.   Sole Dispositive Power 2,350,440
Person With:
                      8.   Shared Dispositive Power

         9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,350,440

         10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)

         11. Percent of Class Represented by Amount in Row (9) 4.22%

         12. Type of Reporting Person (See Instructions) OO

         1. Names of Reporting Persons.
              I.R.S. Identification Nos. of above persons (entities only). John
F. Donahue

         2. Check the Appropriate Box if a Member of a Group (See Instructions)

              (a)...............................................................

              (b)...............................................................

         3.   SEC Use Only......................................................

         4.   Citizenship or Place of Organization: United States

Number of             5.   Sole Voting Power
Shares Bene-
ficially by           6.   Shared Voting Power 2,350,440
Owned by Each
Reporting             7.   Sole Dispositive Power
Person With:
                      8. Shared Dispositive Power 2,350,440

         9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,350,440

         10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)

         11. Percent of Class Represented by Amount in Row (9) 4.22%

         12. Type of Reporting Person (See Instructions) IN

         1. Names of Reporting Persons.
              I.R.S. Identification Nos. of above persons (entities only).
Rhodora J. Donahue

         2. Check the Appropriate Box if a Member of a Group (See Instructions)

              (a)...............................................................

              (b)...............................................................

         3.   SEC Use Only......................................................

         4.   Citizenship or Place of Organization:  United States

Number of             5.   Sole Voting Power
Shares Bene-
ficially by           6.   Shared Voting Power 2,350,440
Owned by Each
Reporting             7.   Sole Dispositive Power
Person With:
                      8. Shared Dispositive Power 2,350,440

         9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,350,440

         10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)

         11. Percent of Class Represented by Amount in Row (9) 4.22%

         12. Type of Reporting Person (See Instructions) IN

         1. Names of Reporting Persons.
              I.R.S. Identification Nos. of above persons (entities only). J.
Christopher Donahue

         2. Check the Appropriate Box if a Member of a Group (See Instructions)

              (a)...............................................................

              (b)...............................................................

         3.   SEC Use Only......................................................

         4.   Citizenship or Place of Organization:  United States

Number of             5.   Sole Voting Power
Shares Bene-
ficially by           6.   Shared Voting Power 2,350,440
Owned by Each
Reporting             7.   Sole Dispositive Power
Person With:
                      8. Shared Dispositive Power 2,350,440

         9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,350,440

         10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)

         11. Percent of Class Represented by Amount in Row (9) 4.22%

         12. Type of Reporting Person (See Instructions) IN









Item 1.

         (a)      Name of Issuer

         ILLUMINA, INC.

         (b)      Address of Issuer's Principal Executive Offices

         9885 Towne Centre Drive

         San Diego, CA 92121

Item 2.

         (a)      Name of Person Filing

         (b) Address of Principal Business Office or, if none, Residence

         Federated Investors Tower, Pittsburgh, PA 15222-3779

         (c)      Citizenship

         (d)      Title of Class of Securities

         Common Stock

         (e)      CUSIP Number

         452327109

Item 3. If this statement is filed pursuant to ss.ss.240.13d-1(b) or
240.13d-2(b) or (c), check whether the person filing is a:

         (a)      ____     Broker or dealer registered under section 15 of the
                           Act (15 U.S.C. 78o).

         (b)      ____     Bank as defined in section 3(a)(6) of the Act
                           (15 U.S.C. 78c).

         (c)      ____     Insurance company as defined in section 3(a)(19) of
                           the Act (15 U.S.C. 78c).

         (d)      ____     Investment company registered under section 8 of the
                           Investment Company Act of 1940 (15 U.S.C 80a-8).

         (e)      ____     An investment adviser in accordance with
                           ss.240.13d-1(b)(1)(ii)(E);

         (f)               ____ An employee benefit plan or endowment fund in
                           accordance with ss.240.13d-1(b)(1)(ii)(F);

         (g)               __X__ A parent holding company or control person in
                           accordance with ss. 240.13d-1(b)(1)(ii)(G);

         (h)      ____     A savings associations as defined in Section 3(b) of
                           the Federal Deposit Insurance Act (12 U.S.C. 1813);

         (i)               ____ A church plan that is excluded from the
                           definition of an investment company under section
                           3(c)(14) of the Investment Company Act of 1940 (15
                           U.S.C. 80a-3);

         (j)               ____ Group, in accordance with
                           ss.240.13d-1(b)(1)(ii)(J).

Item 4.  Ownership.

         Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

         A. Federated Investors, Inc. (See Footnote 1, next page)

         (a) Amount beneficially owned: 2,350,440

         (b) Percent of class: 4.22%

         (c) Number of shares as to which the person has:

                  (i) Sole power to vote or to direct the vote 2,350,440

                  (ii) Shared power to vote or to direct the vote -0-

                  (iii) Sole power to dispose or to direct the disposition of
2,350,440

                  (iv) Shared power to dispose or to direct the disposition of
-0-

         B.  Voting Shares Irrevocable Trust

         (a) Amount beneficially owned: 2,350,440

         (b) Percent of class: 4.22%

         (c) Number of shares as to which the person has:

                  (i) Sole power to vote or to direct the vote 2,350,440

                  (ii) Shared power to vote or to direct the vote -0-

                  (iii) Sole power to dispose or to direct the disposition of
2,350,440

                  (iv) Shared power to dispose or to direct the disposition of
-0-

         C. John F. Donahue

         (a) Amount beneficially owned: 2,350,440

         (b) Percent of class: 4.22%

         (c) Number of shares as to which the person has:

                  (i) Sole power to vote or to direct the vote -0-

                  (ii) Shared power to vote or to direct the vote 2,350,440

                  (iii) Sole power to dispose or to direct the disposition of
-0-

                  (iv) Shared power to dispose or to direct the disposition of
2,350,440

         D. Rhodora J. Donahue

         (a) Amount beneficially owned: 2,350,440

         (b) Percent of class: 4.22%

         (c) Number of shares as to which the person has:

                  (i) Sole power to vote or to direct the vote -0-

                  (ii) Shared power to vote or to direct the vote 2,350,440

                  (iii) Sole power to dispose or to direct the disposition of
-0-

                  (iv) Shared power to dispose or to direct the disposition of
2,350,440

         E. J. Christopher Donahue

         (a) Amount beneficially owned: 2,350,440

         (b) Percent of class: 4.22%

         (c) Number of shares as to which the person has:

                  (i) Sole power to vote or to direct the vote -0-

                  (ii) Shared power to vote or to direct the vote 2,350,440

                  (iii) Sole power to dispose or to direct the disposition of
-0-

                  (iv) Shared power to dispose or to direct the disposition of
2,350,440

         Instruction. For computations regarding securities which represent a
         right to acquire an underlying security see ss.240.13d-3(d)(1).



Item 5.  Ownership of Five Percent or Less of a Class

         If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following _X_.

Instruction:  Dissolution of a group requires a response to this item.

Item 6.  Ownership of More than Five Percent on Behalf of Another Person.
                NOT APPLICABLE

Item 7.  Identification and Classification of the Subsidiary Which Acquired the
         Security Being Reported on By the Parent Holding
         Company  See Exhibit "1" Attached

Item 8.  Identification and Classification of Members of the Group
                NOT APPLICABLE

Item 9. Notice of Dissolution of Group  NOT APPLICABLE

Item 10. Certification

         (a) The following certification shall be included if the statement is
filed pursuant to ss.240.13d-1(b):

                           By signing below I certify that, to the best of my
                           knowledge and belief, the securities referred to
                           above were acquired and are held in the ordinary
                           course of business and were not acquired and are not
                           held for the purpose of or with the effect of
                           changing or influencing the control of the issuer of
                           the securities and were not acquired and are not held
                           in connection with or as a participant in any
                           transaction having that purpose or effect.

         (b) The following certification shall be included if the statement is
filed pursuant to ss.240.13d-1(c):

                           By signing below I certify that, to the best of my
                           knowledge and belief, the securities referred to
                           above were not acquired and are not held for the
                           purpose of or with the effect of changing or
                           influencing the control of the issuer of the
                           securities and were not acquired and are not held in
                           connection with or as a participant in any
                           transaction having that purpose or effect.

                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:  March 10, 2008
By: /s/J. Christopher Donahue
Name/Title:  J. Christopher Donahue, as President of Federated Investors, Inc.


Date:  March 10, 2008
By: /s/John F. Donahue, individually and as Trustee of Voting Shares Irrevocable
Trust, by J. Christopher Donahue, as attorney-in-fact

Date:  March 10, 2008
By: /s/Rhodora J. Donahue, individually and as Trustee of Voting Shares
Irrevocable Trust, by J. Christopher Donahue, as attorney-in-fact


Date:  March 10, 2008
By: /s/J. Christopher Donahue
Name/Title:  J. Christopher Donahue, individually and as Trustee of Voting
Shares Irrevocable Trust


         The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative other than an
executive officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all exhibits.  See  ss.240.13d-7  for other
parties for whom copies are to be sent.

Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001)






                                   EXHIBIT "1"

                            ITEM 3 CLASSIFICATION OF
                                REPORTING PERSONS
              Identity and Classification of Each Reporting Person


IDENTITY                                     CLASSIFICATION UNDER ITEM 3

Advanced Series Trust                 (d) Investment company registered under
                                      section 8 of the Investment Company Act
                                      of 1940 (15 U.S.C. 80a-8).

Federated Equity Funds                (d) Investment company registered under
                                      section 8 of the Investment Company Act
                                      of 1940 (15 U.S.C. 80a-8).

Federated Index Trust                 (d) Investment company registered under
                                      section 8 of the Investment Company Act
                                      of 1940 (15 U.S.C. 80a-8).

Federated Insurance Series            (d) Investment company registered under
                                      section 8 of the Investment Company Act
                                      of 1940 (15 U.S.C. 80a-8).

Federated International Funds, PLC    (g) A parent holding company or control
                                       person in accordance with section
                                       240.13d-1(b)(1)(ii)(G)

Federated Equity Management Company   (e) Investment Adviser registered under
         of Pennsylvania               section 203 of the Investment Advisers
                                       Act of 1940

Federated Global Investment           (e) Investment Adviser registered under
         Management Corp.             section 203 of the Investment Advisers
                                      Act of 1940

Federated Investment Counseling       (e) Investment Adviser registered under
                                      section 203 of the Investment Advisers
                                      Act of 1940

Federated MDTA LLC                    (e) Investment Adviser registered under
                                      section 203 of the Investment Advisers Act
                                      of 1940

Federated Investors, Inc.             (g) Parent Holding Company, in accordance
                                      with Section 240.13d-1(b)(ii)(G)

FII Holdings, Inc.                    (g) Parent Holding Company, in accordance
                                      with Section 240.13d-1(b)(ii)(G)

Voting Shares Irrevocable Trust       (g) Parent Holding Company, in accordance
                                      with Section 240.13d-1(b)(ii)(G)

John F. Donahue                       (g) Parent Holding Company, in accordance
                                      with Section 240.13d-1(b)(ii)(G)

Rhodora J. Donahue                    (g) Parent Holding Company, in accordance
                                      with Section 240.13d-1(b)(ii)(G)

J. Christopher Donahue                (g) Parent Holding Company, in accordance
                                      with Section 240.13d-1(b)(ii)(G)

Federated Investors, Inc. (the "Parent") is filing this Schedule 13G because it
is the parent holding company of Federated Equity Management Company of
Pennsylvania and Federated Global Investment Management Corp. (the "Investment
Advisers"), which act as investment advisers to registered investment companies
and separate accounts that own shares of common stock in ILLUMINA, INC. (the
"Reported Securities'). The Investment Advisers are wholly owned subsidiaries of
FII Holdings, Inc., which is wholly owned subsidiary of Federated Investors,
Inc., the Parent. All of the Parent's outstanding voting stock is held in the
Voting Shares Irrevocable Trust (the "Trust") for which John F. Donahue, Rhodora
J. Donahue and J. Christopher Donahue act as trustees (collectively, the
"Trustees"). The Trustees have joined in filing this Schedule 13G because of the
collective voting control that they exercise over the Parent. In accordance with
Rule 13d-4 under the Securities Act of 1934, as amended, the Parent, the Trust,
and each of the Trustees declare that this statement should not be construed as
an admission that they are the beneficial owners of the Reported Securities, and
the Parent, the Trust, and each of the Trustees expressly disclaim beneficial
ownership of the Reported Securities






                                   EXHIBIT "2"

                          AGREEMENT FOR JOINT FILING OF

                                  SCHEDULE 13G

         The following parties hereby agree to file jointly the statement on
Schedule 13G to which this Agreement is attached and any amendments thereto
which may be deemed necessary pursuant to Regulation 13D-G under the Securities
Exchange Act of 1934:

         1. Federated Investors, Inc. as parent holding company of the
investment advisers to registered investment companies that beneficially own the
securities.

Voting Shares Irrevocable Trust, as holder of all the voting shares of Federated
Investors, Inc.

John F. Donahue, individually and as Trustee

Rhodora J. Donahue, individually and as Trustee

J. Christopher Donahue, individually and as Trustee

         It is understood and agreed that each of the parties hereto is
responsible for the timely filing of such statement and any amendments thereto,
and for the completeness and accuracy of the information concerning such party
contained therein, but such party is not responsible for the completeness or
accuracy of information concerning the other parties unless such party knows or
has reason to believe that such information is incomplete or inaccurate.

         It is understood and agreed that the joint filing of Schedule 13G shall
not be construed as an admission that the reporting persons named herein
constitute a group for purposes of Regulation 13D-G of the Securities Exchange
Act of 1934, nor is a joint venture for purposes of the Investment Company Act
of 1940.

Date:    March 10, 2008

By:      /s/J. Christopher Donahue
Name/Title: J. Christopher Donahue, as President of Federated Investors, Inc.

By:      /s/John F. Donahue
Name/Title:       John F. Donahue, individually and as Trustee of Voting Shares
Irrevocable Trust, by J. Christopher Donahue, as attorney-in-fact.

By:      /s/      Rhodora J. Donahue
Name/Title:       Rhodora J. Donahue, individually and as Trustee as Voting
Shares Irrevocable Trust, by J. Christopher Donahue, as attorney-in-fact.

By:      /s/      J. Christopher Donahue
Name/Title:       J. Christopher Donahue, individually and as Trustee of Voting
Shares Irrevocable Trust

1. The number of shares indicated represent shares beneficially owned by
registered investment companies and separate accounts advised by subsidiaries of
Federated Investors, Inc. that have been delegated the power to direct
investments and power to vote the securities by the registered investment
companies' board of trustees or directors and by the separate accounts'
principals. All of the voting securities of Federated Investors, Inc. are held
in the Voting Shares Irrevocable Trust ("Trust"), the trustees of which are John
F. Donahue, Rhodora J. Donahue, and J. Christopher Donahue ("Trustees'). In
accordance with Rule 13d-4 under the 1934 Act, the Trust, Trustees, and parent
holding company declare that the filing of this statement should not be
construed as an admission that any of the investment advisers, parent holding
company, Trust, and Trustees are beneficial owners (for the purposes of Sections
13(d) and/or 13(g) of the Act) of any securities covered by this statement, and
such advisers, parent holding company, Trust, and Trustees expressly disclaim
that they are the beneficial owners such securities.






                                    EXHIBIT 3

                                POWER OF ATTORNEY

         Each person who signature appears below hereby constitutes and appoints
J. Christopher Donahue their true and lawful attorney-in-fact and agent, with
full power of substitution and resubstitution for them and in their names, place
and stead, in any and all capacities, to sign any and all Schedule 13Ds and/or
Schedule 13Gs, and any amendments thereto, to be filed with the Securities and
Exchange commission pursuant to Regulation 13D-G of the Securities Exchange Act
of 1934, as amended, by means of the Securities and Exchange Commission's
electronic disclosure system known as EDGAR; and to file the same, with all
exhibits thereto and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorney-in-fact and
agent, full power and authority to sign and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as each of them might or could do in person, hereby
ratifying and confirming all that said attorney-in-fact and agent, or their or
his substitute or substitutes, may lawfully do or cause to be done by virtue
thereof.


SIGNATURES                                        TITLE OR CAPACITY

/s/John F. Donahue                               Individually and as Trustee of
-------------------------------------------------
John F. Donahue                          the Voting Shares Irrevocable Trust

/s/Rhodora J. Donahue                            Individually and as Trustee of
-------------------------------------------------
Rhodora J. Donahue                       the Voting Shares Irrevocable Trust


Sworn to and subscribed before me this 23rd day of September, 2004.

/s/Madaline P. Kelly
Notary Public
My Commission Expires: February 22, 2008