SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                               (Amendment No. 23)*

                            ISCO International, Inc.
                                (Name of Issuer)

                          Common Stock, par value $.001
                         (Title of Class of Securities)

                                    46426P103
                                 (CUSIP Number)

                            Stephen M. Schultz, Esq.
                     Kleinberg, Kaplan, Wolff & Cohen, P.C.,
                   551 Fifth Avenue, New York, New York 10176
                               Tel: (212) 986-6000
(Name, Address and Telephone Number of Person Authorized to Receive Notices and
                                Communications)

                                  June 29, 2006
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
[ ].

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



1.  NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
        Elliott Associates, L.P.

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
        (a)[x]
        (b)[ ]

3.  SEC USE ONLY

4.  SOURCE OF FUNDS*
        WC

5.  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
    ITEMS 2(d) or 2(e) [ ]

6.  CITIZENSHIP OR PLACE OF ORGANIZATION
        Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.  SOLE VOTING POWER
        22,932,926

8.  SHARED VOTING POWER
        0

9.  SOLE DISPOSITIVE POWER
        22,932,926

10. SHARED DISPOSITIVE POWER
        0

11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        22,932,926

12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
    SHARES* [ ]

13. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        12.0%

14. TYPE OF REPORTING PERSON*
        PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.  NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
        Elliott International, L.P.

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
        (a)[x]
        (b)[ ]

3.  SEC USE ONLY

4.  SOURCE OF FUNDS*
        WC

5.  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
    PURSUANT TO ITEMS 2(d) or 2(e) [ ]

6.  CITIZENSHIP OR PLACE OF ORGANIZATION Cayman Islands, British
        West Indies

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.  SOLE VOTING POWER
        0

8.  SHARED VOTING POWER
        19,904,159

9.  SOLE DISPOSITIVE POWER
        0

10. SHARED DISPOSITIVE POWER
        19,904,159

11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        19,904,159

12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
    SHARES* [ ]

13. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        10.8%

14. TYPE OF REPORTING PERSON*
        PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.  NAME OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
        Elliott International Capital Advisors, Inc.

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
        (a)[x]
        (b)[ ]

3.  SEC USE ONLY

4.  SOURCE OF FUNDS*
        00

5.  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
    ITEMS 2(d) or 2(e) [ ]

6.  CITIZENSHIP OR PLACE OF ORGANIZATION
        Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.  SOLE VOTING POWER
        0

8.  SHARED VOTING POWER
        19,904,159

9.  SOLE DISPOSITIVE POWER
        0

10. SHARED DISPOSITIVE POWER
        19,904,159

11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        19,904,159

12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
    SHARES* [ ]

13. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
        10.8%

14. TYPE OF REPORTING PERSON*
        CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



     This  statement is filed with respect to the shares of common stock,  $.001
par value  (the  "Common  Stock") of ISCO  International,  Inc.  (the  "Issuer")
beneficially owned by Elliott Associates, L.P. and its wholly-owned subsidiaries
(collectively, "Elliott"), Elliott International, L.P. ("Elliott International")
and Elliott  International  Capital Advisors,  Inc.  ("EICA")(collectively,  the
"Reporting Persons") as of July 17, 2006 and amends and supplements the Schedule
13D dated April 7, 1999, as previously  amended (the "Schedule 13D").  Except as
set forth herein, the Schedule 13D, as previously amended, is unmodified.

ITEM 2.  Identity and Background.

(a)-(c) This  statement is being filed by Elliott  Associates,  L.P., a Delaware
limited   partnership,   and  its   wholly-owned   subsidiaries   (collectively,
"Elliott"),  Elliott  International,  L.P., a Cayman Islands limited partnership
("Elliott  International"),  and Elliott  International Capital Advisors Inc., a
Delaware   corporation   ("EICA"  and  collectively  with  Elliott  and  Elliott
International,  the "Reporting  Persons").  Paul E. Singer  ("Singer"),  Elliott
Capital Advisors,  L.P., a Delaware limited  partnership  ("Capital  Advisors"),
which is controlled by Singer,  and Elliott  Special GP, LLC ("Special GP"), are
the general partners of Elliott.  Hambledon,  Inc., a Cayman Islands corporation
("Hambledon"),  which is also controlled by Singer,  is the sole general partner
of  Elliott   International.   EICA  is  the  investment   manager  for  Elliott
International.  EICA expressly  disclaims  equitable  ownership of and pecuniary
interest in any shares of Common Stock.

     ELLIOTT

     The business address of Elliott is 712 Fifth Avenue,  36th Floor, New York,
New York 10019.

     The principal business of Elliott is to purchase, sell, trade and invest in
securities.

     SINGER

     Singer's  business  address is 712 Fifth Avenue,  36th Floor, New York, New
York 10019.

     Singer's principal business is to serve as a general partner of Elliott and
Capital Advisors,  as the president of EICA, and as a managing member of Special
GP.

     CAPITAL ADVISORS

     The business address of Capital  Advisors is 712 Fifth Avenue,  36th Floor,
New York, New York 10019.

     The principal  business of Capital Advisors is the furnishing of investment
advisory services.  Capital Advisors also serves as a managing member of Special
GP.



     The  names,  business  addresses,   and  present  principal  occupation  or
employment of the general partners of Capital Advisors are as follows:

    NAME                 ADDRESS                        OCCUPATION
Paul E. Singer      712 Fifth Avenue             General partner of Elliott
                    36th Floor                   and Capital Advisors;
                    New York, New York 10019     President of EICA; and a
                                                 managing member of Special GP

Braxton            712 Fifth Avenue              The principal business of
Associates, Inc.   36th Floor                    Braxton Associates, Inc. is
                   New York, New York 10019      serving as general partner
                                                 of Capital Advisors

Elliott Asset      712 Fifth Avenue              General Partner of Capital
Management LLC     36th Floor                    Advisors
                   New York, New York  10019

     The name, business address,  and present principal occupation or employment
of the sole director and executive  officer of Braxton  Associates,  Inc. are as
follows:

    NAME                 ADDRESS                        OCCUPATION
Paul E. Singer      712 Fifth Avenue             General partner of Elliott
                    36th Floor                   and Capital Advisors;
                    New York, New York 10019     President of EICA

     ELLIOTT SPECIAL GP, LLC

     The business  address of Special GP is 712 Fifth  Avenue,  36th Floor,  New
York, New York 10019.

     The  principal  business  of Special GP is serving as a general  partner of
Elliott.

     The names, business address, and present principal occupation or employment
of the managing members of Special GP are as follows:

    NAME                 ADDRESS                        OCCUPATION
Paul E. Singer      712 Fifth Avenue             General partner of Elliott
                    36th Floor                   and Capital Advisors;
                    New York, New York 10019     President of EICA; and a
                                                 managing member of Special GP

Braxton            712 Fifth Avenue              The principal business of
Associates, Inc.   36th Floor                    Braxton Associates, Inc. is
                   New York, New York 10019      serving as general partner
                                                 of Capital Advisors

Elliott Asset      712 Fifth Avenue              General Partner of Capital
Management LLC     36th Floor                    Advisors
                   New York, New York  10019

     ELLIOTT INTERNATIONAL

     The business  address of Elliott  International is c/o c/o Maples & Calder,
P.O. Box 309,  Ugland House,  South Church  Street,  George Town,  Grand Cayman,
Cayman Islands, British West Indies.

     The principal business of Elliott International is to purchase, sell, trade
and invest in securities.

     The name, business address,  and present principal occupation or employment
of the general partner of Elliott International is as follows:

     NAME                       ADDRESS                      OCCUPATION
Hambledon, Inc.      c/o Maples & Calder, P.O.      General partner of Elliott
                     Box 309, Ugland House, South   International
                     Church Street, George Town,
                     Grand Cayman, Cayman
                     Islands, British West Indies



     HAMBLEDON

     The name, business address,  and present principal occupation or employment
of the sole director and executive officer of Hambledon are as follows:

    NAME                 ADDRESS                        OCCUPATION
Paul E. Singer      712 Fifth Avenue             General partner of Elliott
                    36th Floor                   and Capital Advisors;
                    New York, New York 10019     President of EICA; and a
                                                 managing member of Special GP
     EICA

     The business address of EICA is 712 Fifth Avenue, 36th Floor, New York, New
York 10019.

     The principal  business of EICA is to act as investment manager for Elliott
International.

     The name, business address,  and present principal occupation or employment
of the sole director and executive officer of EICA is as follows:


    NAME                 ADDRESS                        OCCUPATION
Paul E. Singer      712 Fifth Avenue             General partner of Elliott
                    36th Floor                   and Capital Advisors;
                    New York, New York 10019     President of EICA; and a
                                                 managing member of Special GP

     (d) and (e) During the last five  years,  none of the  persons or  entities
listed above or, to the  knowledge  of such  persons or  entities,  has been (i)
convicted in a criminal  proceeding  (excluding  traffic  violations  or similar
misdemeanors);  or  (ii)  a  party  to  a  civil  proceeding  of a  judicial  or
administrative body of competent jurisdiction and as a result of such proceeding
was or is  subject  to a  judgment,  decree  or  final  order  enjoining  future
violations  of, or prohibiting  or mandating  activities  subject to, federal or
state securities laws or finding any violation with respect to such laws.

     (f) Mr. Singer is a citizen of the United States of America.



ITEM 3.  Source and Amount of Funds or Other Consideration

     The source and amount of funds used by Elliott in making its  purchases  of
the shares of Common Stock beneficially owned by it are set forth below:

SOURCE OF FUNDS                       AMOUNT OF FUNDS
Working Capital                       $5,771,431

     The source and amount of funds used by Elliott  International in making its
purchases of the shares of Common Stock  beneficially  owned by it are set forth
below:

SOURCE OF FUNDS                       AMOUNT OF FUNDS
Working Capital                       $7,515,272

ITEM 4.  Purpose of Transaction.

     Each of  Elliott  and  Elliott  International  acquired  the  Common  Stock
beneficially  owned by it in the  ordinary  course of its trade or  business  of
purchasing,  selling,  trading and  investing in  securities.  EICA has acted as
investment  manager  with  respect to  Elliott  International's  acquisition  of
beneficial ownership of Common Stock.

     Depending  upon  market  conditions  and  other  factors  that it may  deem
material,  each of Elliott and Elliott  International  may  purchase  additional
shares of Common Stock or related  securities or may dispose of all or a portion
of the Common Stock or related  securities that it now beneficially  owns or may
hereafter acquire.

     On  June  22,  2006,   Manchester   Securities  Corp.   ("Manchester"),   a
wholly-owned subsidiary of Elliott, entered into a Securities Purchase Agreement
("Securities  Purchase  Agreement") with the Issuer and another party identified
therein, pursuant to which Manchester agreed to purchase $2,500,000 in principal
amount  of a  5%  Senior  Secured  Convertible  Note  due  June  22,  2010  (the
"Convertible  Note").  The purchase of the  Convertible  Note closed on June 29,
2006. The Convertible Note converts into shares of Common Stock at a rate of the
then  outstanding  principal  amount divided by the then conversion  price.  The
conversion  price is $0.33.  Accrued  interest shall be added to the outstanding
principal amount of the Convertible Note. The conversion of the Convertible Note
is also subject to anti-dilution provisions and is convertible immediately.  The
Common Stock into which the  Convertible  Note converts shall be registered with
the  Securities  and  Exchange  Commission  ("SEC")  pursuant  to the terms of a
Registration Rights Agreement.

     On June 22, 2006,  Manchester  also entered into an Amendment to and Waiver
Under the Third Amended and Restated Loan Agreement (the "Loan  Agreement") with
the Issuer and another party  identified  therein,  pursuant to which Manchester
and another lender agreed to (i) waive the Issuer's obligation to prepay certain
notes  issued to the lenders  under the Loan  Agreement in  accordance  with the
terms of the Loan  Agreement,  and (ii) waive the restriction on the Issuer from
making loans to other parties pursuant to the terms of the Loan Agreement.

     The above  agreements and their related  documents are more fully described
in the Issuer's 8-K filed with the SEC on June 28, 2006.



     Except as set forth herein and as previously disclosed on the Schedule 13D,
none of Elliott,  Elliott International or EICA has any plans or proposals which
relate to or would result in any of the actions set forth in  subparagraphs  (a)
through (j) of Item 4.

ITEM 5.  Interest in Securities of the Issuer.

     (a) Elliott  beneficially  owns an aggregate of 22,932,926 shares of Common
Stock,  comprised of: (i) 15,357,168  shares of Common Stock, and (ii) 7,575,758
shares of Common Stock into which the Convertible Note converts.  The 22,932,926
shares of Common Stock  constitutes  12.0% of all of the  outstanding  shares of
Common Stock.

     Together,  Elliott  International and EICA beneficially own an aggregate of
19,904,159 shares of Common Stock,  constituting 10.8% of all of the outstanding
shares of Common Stock.

     Elliott, Elliott International and EICA's aggregate beneficial ownership of
Common  Stock  equals  42,837,085  shares,   comprising  22.3%  of  all  of  the
outstanding shares of Common Stock.

     (b)  Elliott has the power to vote or direct the vote of, and to dispose or
direct the disposition of, the shares of Common Stock beneficially owned by it.

     Elliott  International has the shared power with EICA to vote or direct the
vote of, and to dispose or direct the disposition of, the shares of Common Stock
owned  by  Elliott   International.   Information   regarding  each  of  Elliott
International  and  EICA is set  forth  in Item 2 of  this  Schedule  13D and is
expressly incorporated herein by reference herein.

     (c) There  have been no  transactions  effected  by the  Reporting  Persons
within  the  past 60 days  other  than  the  purchase  of the  Convertible  Note
described in Item 4. The purchase of the Convertible Note was effected through a
privately negotiated transaction with the Issuer (see Item 4 above).

     (d) No person  other than  Elliott has the right to receive or the power to
direct the receipt of  dividends  from,  or the  proceeds  from the sale of, the
shares of Common Stock beneficially owned by Elliott.

     No  person  other  than  Elliott  International  and EICA has the  right to
receive or the power to direct the receipt of  dividends  from,  or the proceeds
from the sale of,  the  shares of Common  Stock  beneficially  owned by  Elliott
International and EICA.

     (e) Not applicable.

ITEM 6.  Contracts, Arrangements, Understandings or Relationships With Respect
         to Securities of the Issuer.

     Except as otherwise described in this Schedule 13D, there are no contracts,
arrangement,  understandings or relationships  with respect to securities of the
Issuer.



                                   SIGNATURES

     After reasonable  inquiry and to the best of its knowledge and belief,  the
undersigned  each certifies that the information with respect to it set forth in
this statement is true, complete and correct.

Dated: July 17, 2006

         ELLIOTT ASSOCIATES, L.P.
         By: Elliott Capital Advisors, L.P., as General Partner
                  By: Braxton Associates, Inc., as General Partner


                           By: /s/ Elliot Greenberg
                               --------------------
                                   Elliot Greenberg
                                   Vice President


         ELLIOTT INTERNATIONAL, L.P.
         By:      Elliott International Capital Advisors Inc.,
                           as Attorney-in-Fact


                           By: /s/ Elliot Greenberg
                               --------------------
                                   Elliot Greenberg
                                   Vice President


         ELLIOTT INTERNATIONAL CAPITAL ADVISORS INC.


         By: /s/ Elliot Greenberg
             --------------------
                 Elliot Greenberg
                 Vice President